Suspected ( but unproven ) Invasive Candida Infection - Guideline for the Management of
|Last review: 13/07/2018|
|Next review: 13/07/2021|
|Approved By: Improving Antimicrobial Prescribing Group|
|Copyright© Leeds Teaching Hospitals NHS Trust 2018|
This Clinical Guideline is intended for use by healthcare professionals within Leeds unless otherwise stated.
Guideline for the Management of Suspected (but unproven) Invasive Candida Infection
Table of drug doses
For interactions and side effects of ambisome see BNF 2009
Candida Infections in neonates
|Target patient group:||Neonates|
|Target professional group(s):||Secondary Care Doctors
- Healy et al. Fluconazole Prophylaxis in Extremely Low Birth Weight Neonates Reduces Invasive Candidiasis Mortality Rates Without Emergence of Fluconazole-Resistant Candida Species. Pediatrics 2008;121;703-710
- Stoll et al. Late-onset sepsis in VLBW neonates: the experience of the NICHD Neonatal Research Network. Pediatrics 2002; 110(2);285-291
- Manzoni et al. A Multicentre, Randomized Trial of Prophylactic Fluconazole in Preterm Neonates. N Engl J med 356;24: 2483-249
- Kicklighter et al. Fluconazole for Prophylaxis Against Candidal Rectal Colonisation in the VLBW Infant. Paediatrics 2001;107:293-8
- L Clerihew, T L Lamagni, P Brocklehurst, and W McGuire. Invasive fungal infection in very low birthweight infants: national prospective surveillance study. Arch. Dis. Child. Fetal Neonatal Ed 2006
- Clerihew L, McGuire W. Systemic antifungal drugs for invasive fungal infection in preterm infants. Cochrane Database Syst Rev 2004;1
- Pappas PG et al. Guidelines for the treatment of candidiasis.
- Makhoul et al. Review of 49 Neonates with acquired fungal sepsis: further characterization. Paediatrics 2001; 107:61-66
- Rex JH, Walsh, TJ, Sobel JD. Practice guidelines for the treatment of candidiasis.
- Karlowicz, MG et al. Should central venous catheters be removed as soon as candidaemia is detected in neonates? Pediatrics 2000;106(5) e63
- McGuire W, Clerihew L, Austin N. Prophylactic intravenous antifungal agents to prevent mortality and morbidity in very low birth weight infants (Cochrane review). In The Cochrane Library, issue 1, 2003. Oxford: Updated software.
- F Adler-Shohet, H Waskin, and J M Lieberman. Amphotericin B lipid complex for neonatal invasive candidiasis. Arch. Dis. Child. Fetal Neonatal Ed., 2001; 84: 131 - 133.
- N. Linder, G. Klinger, I. Shalit, I. Levy, S. Ashkenazi, G. Haski, O. Levit, and L. Sirota
Treatment of candidaemia in premature infants: comparison of three amphotericin B preparations. J. Antimicrob. Chemother. 2003; 52(4): 663 - 667.
- D. Kaufman and K. D. Fairchild. Clinical Microbiology of Bacterial and Fungal Sepsis in Very-Low-Birth-Weight Infants. Clin. Microbiol. Rev.2004; 17(3): 638 - 680.
- H Smith and P Congdon. Neonatal systemic candidiasis. Arch. Dis. Child. 1985; 60: 365 - 369.
- Huttova M, Hartmanova I, Kralinsky K, et al. Candida fungemia in neonates treated with fluconazole: report of forty cases, including eight with meningitis. Pediatr Infect Dis J.1998; 17 :1012 –1015
- L Clerihew, T L Lamagni, P Brocklehurst, and W McGuire. Candida parapsilosis infection in very low birthweight infants. Arch. Dis. Child. Fetal Neonatal Ed.2007; 92(2): 127 - 129. NB – This last article states that C. parapsilosis is best treated with Ambisome but this doesn’t conform to previous guidelines??
A. Meta-analyses, randomised controlled trials/systematic reviews of RCTs
B. Robust experimental or observational studies
C. Expert consensus.
Improving Antimicrobial Prescribing Group
LHP version 1.0
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