MRSA Risk - guidance on selection of antimicrobial prophylaxis and empirical treatment regimens

Publication: 05/02/2009  
Next review: 29/01/2026  
Clinical Guideline
ID: 1453 
Approved By: Improving Antimicrobial Prescribing Group and Infection Control 
Copyright© Leeds Teaching Hospitals NHS Trust 2019  


This Clinical Guideline is intended for use by healthcare professionals within Leeds unless otherwise stated.
For healthcare professionals in other trusts, please ensure that you consult relevant local and national guidance.

MRSA risk - guidance on selection of antimicrobial prophylaxis and empirical treatment regimens

Risk Factors

Patients within these categories are considered at increased risk of MRSA infection:

  1. Known colonisation with MRSA at any site at any time.
  2. Known previous infection with MRSA (requiring antimicrobial treatment) at any time.
  3. Resident of a long term care facility (nursing home, residential home or any other long term residential facility) without a negative MRSA screening result.
  4. Current inpatient and in hospital for greater than 14 days.

If a patient has risk factors for MRSA infection:

  • MRSA should be considered when choosing empirical (best guess) antimicrobial treatment regimens for infection.
  • They should receive surgical prophylaxis with activity against MRSA as specified in specialty-specific prophylaxis guidelines.
  • Where no specialty specific prophylaxis guidelines exists teicoplanin IV bolus 400mg within 1 hour prior to incision/tourniquet application as a single dose may be appropriate, discussion with microbiology is advised.
  • Where patient is allergic to teicoplanin seek microbiology advice.
  • Topical decolonisation should be administered according to the screening and decolonisation protocol.


Record: 1453
Clinical condition:
Target patient group: All patients
Target professional group(s): Pharmacists
Secondary Care Doctors
Secondary Care Nurses
Adapted from:

Evidence base

Not supplied

Approved By

Improving Antimicrobial Prescribing Group and Infection Control

Document history

LHP version 1.0

Related information

Not supplied

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